Michael Dworzak Group

Michael Dworzak
email: michael.dworzak(at)ccri.at

Immunological Diagnostics

We develop new diagnostic methods for children and adolescents with leukemia and lymphomas using flow cytometry immunophenotyping.

Team

Our working group’s research focus deals with the development and validation of new diagnostic methods based on flow cytometry. We focus mainly on leukaemia and lymphomas, which make up about 50% of all cases of cancer in children and adolescents. In summary, the topics of our work are investigations into disease-associated peculiarities of protein expression, which could in future be exploited clinically for elaborate diagnostics, risk stratification and treatment tailoring to individual needs. Our scientific focus also lies on the goal of developing new therapies for children and adolescents with leukaemia and lymphomas.

Selected Articles

A. Schumich°, M. Prchal-Murphy°, M. Maurer-Granofszky, A°. Hoelbl-Kovacic°, N. Muhlegger, U. Potschger, S. Fajmann, O.A. Haas, K. Nebral, N. von Neuhoff, M. Zimmermann, H. Boztug, M. Rasche, M. Dolezal, C. Walter, D. Reinhardt, V. Sexl*, and M.N. Dworzak*, Phospho-Profiling Linking Biology and Clinics in Pediatric Acute Myeloid Leukemia. Hemasphere, 2020. 4(1): p. e312. °equally contributed as first authors, * equally contributed as corresponding authors
B. Buldini, M. Maurer-Granofszky, E. Varotto, M.N. Dworzak. Flow-cytometric monitoring of minimal residual disease in pediatric patients with acute myeloid leukemia: Recent advances and future strategies. Front Pediatr. 2019 Oct 11;7:412.doi: 10.3389/fped.2019.00412. eCollection 2019
M. Reiter°, M. Diem°, A. Schumich°, M. Maurer-Granofszky°, L. Karawajew, J.G. Rossi, R. Ratei, S. Groeneveld-Krentz, E.O. Sajaroff, S. Suhendra, M. Kampel, M.N. Dworzak, International Berlin-Frankfurt-Munster (i-BFM) Flow network and the AutoFlow consortium, Automated Flow Cytometric MRD Assessment in Childhood Acute B- Lymphoblastic Leukemia Using Supervised Machine Learning. Cytometry A, 2019. 95(9): p. 966-975. °equally contributed as first authors
D. Schinnerl°, E. Mejstrikova°, A. Schumich°, M. Zaliova, K. Fortschegger, K. Nebral, A. Attarbaschi, K. Fiser, M.O. Kauer, N. Popitsch, S. Haslinger, A. Inthal, B. Buldini, G. Basso, J.P. Bourquin, G. Gaipa, M. Brüggemann, T. Feuerstein, M. Maurer-Granofszky ,R. Panzer-Grümayer, J. Trka, G. Mann, O.A. Haas, O. Hrusak, M.N. Dworzak*, S. Strehl°. CD371 cell surface expression: a unique feature of DUX4-rearranged acute lymphoblastic leukemia. Haematologica. 2019 Aug;104(8):e*52-e355. doi: 10.3324/haematol.2018.214353. Epub 2019 Jan 31.Haematologica. 2019. PMID: 30705095. °equally contributed as first authors, * equally contributed as corresponding authors
M. N. Dworzak, B. Buldini, G. Gaipa, R. Ratei, O. Hrusak, D. Luria, E. Rosenthal, J.P. Bourquin, M. Sartor, A. Schumich, L. Karawajew, E. Mejstrikova, O. Maglia, G. Mann, W.D: Ludwig, A. Biondi, M. Schrappe, G. Basso; International-BFM-FLOW-network. AIEOP-BFM consensus guidelines 2016 for flow cytometric immunophenotyping of Pediatric acute lymphoblastic leukemia. Cytometry B Clin Cytom. 2018 Jan;94(1):82-93. doi: 10.1002/cyto.b.21518. Epub 2017 Feb 21.Cytometry B Clin Cytom. 2018. PMID: 28187514