Technical Assistant / Lab Manager (m/f/d) in the area of epigenome-based precision medicine

Technical Assistant / Lab Manager (m/f/d) in the area of epigenome-based precision medicine

Place:
Vienna

Research group:
Eleni Tomazou Group

Working hours:
Full time

We are recruiting a Technical Assistant / Lab Manager (m/f/d) to join our work on establishing a research program on epigenome-based precision medicine focusing on pediatric tumors. Our lab is based at the Children's Cancer Research Institute (CCRI) of the St. Anna Kinderkrebsforschung Association in Vienna (Austria). The Institute is located in the heart of beautiful Vienna, a European metropolis full of history, music and fine arts. CCRI is a renowned research institution with tight links to the St. Anna Children's Hospital, a leading pediatric cancer center in Europe and well connected through various European and international networks. The ultimate aim of our research at CCRI is to improve treatment outcome of malignant diseases in children and adolescents by performing basic, translational and clinical research. Additional information on the CCRI can be found at http://science.ccri.at/.

 

Under the leadership of Eleni M. Tomazou, the Epigenome-based Precision Medicine lab at CCRI dissects epigenetic deregulation as an oncogenic mechanism, with a focus on fusion-driven pediatric sarcomas. The group studies how fusion proteins rewire healthy cells for malignancy, with the perspective of exploiting this knowledge for improving pediatric sarcoma therapy. Cutting edge technologies and several model systems are exploited to investigate:

  • Non-genetic mechanisms of tumor formation orchestrated by oncogenic fusion proteins
  • Contribution of the cellular state of the corresponding cell of origin to cancer development
  • Epigenetic heterogeneity as source of cellular plasticity providing novel therapeutic paradigms
  • Non-genetic based biomarkers for patient stratification and real time disease monitoring

 

Relevant publications

Sheffield NC, Pierron G, Klughammer J, Datlinger P, Schönegger A, Schuster M, Hadler J, Guillemot D, Lapouble E, Freneaux P, Champigneulle J, Bouvier R, Walder D, Ambros IM, Hutter C, Sorz E, Amaral AT, Álava Ed, Schallmoser K, Strunk D, Rinner B, Liegl-Atzwanger B, Huppertz B, Leithner A, Pinieux Gd, Terrier P, Laurence V, Michon J, Ladenstein R, Holter W, Windhager R, Dirksen U, Ambros PF, Delattre O, Kovar H, Bock C, Tomazou EM. DNA methylation heterogeneity defines a disease spectrum in Ewing sarcoma. Nature Medicine. 2017 Mar;23(3):386-395.

 

Tomazou EM, Sheffield NC, Schmidl C, Schuster M, Schönegger A, Datlinger P, Kubicek S, Bock C, and Kovar H. Epigenome mapping reveals distinct modes of gene regulation and widespread enhancer reprogramming by the oncogenic fusion protein EWS-FLI1. Cell Reports. 2015 Feb 24;10(7):1082-95

Your responsibilities

  • Contribute wet-lab work and expertise to collaborative research projects
  • Optimization and testing of new protocols, e.g. for epigenome editing
  • Actively participate in group meetings and scientific discussions
  • Contribute to the preparation of scientific manuscripts
  • Lab management, e.g. ordering and maintenance of lab inventories
  • Training of new lab members in established and new protocols

Your profile

  • Bachelor or Master degree (or equivalent) in life sciences with strong wet-lab experience
  • High accuracy, reliability, precision under time pressure, and strong organizational skills
  • High motivation and commitment, proactive mindset, getting-things-done attitude
  • Friendly, collaborative mindset and ability to work well in an international environment
  • Experience with DNA/RNA assays including library preparation for next generation sequencing is a plus
  • Excellent tissue culture skills working with cancer cell lines and primary human cells
  • Familiarity with CRISPR-based technologies is a plus but can also be learnt on the job
  • Written and oral communication skills in English (German not required)

Our offer

  • A meaningful, inspiring, and international environment
  • An outstanding working atmosphere in a strong team with excellent research and development opportunities
  • Access to state-of-the-art infrastructure
  • Flexible working hours, discounted lunch in our canteen and other great benefits
  • Great location in the center of Vienna, a capital of biomedical research in Europe with excellent quality of life
  • A fair and attractive salary package starting at € 2.500,-- gross (14x per year) on full-time basis with a view to increase based on your qualification and experience

Who we are

The St. Anna Children’s Cancer Research Institute (CCRI), located in the center of Vienna, the world’s most livable city and one of Europe’s most important places for biomedical research and life sciences, is an international and multidisciplinary competence center striving to improve treatment of children and adolescents with cancer by connecting translational and clinical research with open-minded exploration of basic disease mechanisms. Through close cooperation between clinic and research, the CCRI provides an ideal environment for cutting-edge research and its translation into clinical practice. To achieve our ultimate goal of advancing the well-being of patients, the CCRI constantly pushes scientific boundaries and strongly promotes close collaboration and exchange with external institutions like the Medical University of Vienna, CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, the Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA) and the Institute of Molecular Pathology (IMP).

 

The CCRI is an equal opportunity employer. We value diversity and are committed to providing a work environment of mutual respect to everyone without regard to race, color, religion, national origin, age, gender identity or expression, disability, or any other characteristic protected by applicable laws, regulations and ordinances.

 

Find more information here: https://science.ccri.at/ or https://kinderkrebsforschung.at/.

Your application

Please send your application via email to Eleni Tomazou, application@ccri.at. Applications should at least contain your Curriculum Vitae and a cover letter. Application deadline is 15th of March 2021. Applications are reviewed on a rolling basis until the position is filled.