Assoc. Prof. Dave Aryee, PhD

Priv.-Doz. Dr. Dave Aryee (PhD)

Influence of the microenvironment on gene regulatory networks in Ewing sarcoma

Our research focuses on addressing the basic mechanisms of Ewing sarcoma development in children, with special emphasis on the contribution of the microenvironment, that may ultimately provide the basic knowledge for developing novel therapeutic approaches.

Email: dave.aryee(at)ccri.at

Staff Scientist of the group: Molecular Biology of Solid Tumours

Selected Articles

Aryee DNT, Niedan S, Ban J, Schwentner R, Muehlbacher K, Kauer M, Kofler R, Kovar H.
Variability in functional p53 reactivation by Prima-1Met/APR-246 in Ewing sarcoma.
Brit J Cancer (2013) 00, 1-9 ǀ doi: 10.1038/bjc.2013.635 (In press)

Niedan S, Kauer M, Aryee DNT, Kofler R, Schwentner R, Meier A, Pötschger U, Kontny U, Kovar H. (2013).
Suppression of FOXO1 is responsible for a growth regulatory repressive transcriptional sub-signature of EWS-FLI1 in Ewing sarcoma.
Oncogene. 2013 Sep 2. doi: 10.1038/onc.2013.361. [Epub ahead of print]

Herrero-Martin D, Fourtouna A, Niedan S, Riedmann LT, Schwentner R, Aryee DNT.
Factors affecting EWS-FLI1 activity in Ewing’s sarcoma.
Sarcoma 2011:352580 (2011). doi: 10.1155/2011/352580

Bennani-Baiti IM, Aryee DNT, Ban J, Machado I, KauerM, Mühlbacher K, Amann G, Llombart-Bosch A, Kovar H.
Notch signalling is off and is uncoupled from HES1 expression in Ewing’s sarcoma.
Journal of Pathology 225: 353-363 (2011)

Ban J, Jug G, Mestdagh P, Schwentner R, Kauer M, Aryee DNT, Schaefer K-L, Nakatani F, Scotlandi K, Reiter M, Strunk D, Speleman F, Vandesompele J, Kovar H.
Hsa-mir-145 is the top EWS-FLI1-repressed microRNA involved in a positive feedback loop in Ewing’s sarcoma.
Oncogene 30(18):2173-80 (2011)

Aryee DNT, Niedan S, Kauer M, Schwentner R, Bennani-Baiti IM, Ban J, Muehlbacher M, Kreppel M, Walker RL, Meltzer P, Poremba C, Kofler R, Kovar H.
Hypoxia modulates EWS-FLI1 transcriptional signature and enhances the malignant properties of Ewing’s sarcoma cells in vitro.
Cancer Research 70(10):4015-4023 (2010)

Bennani-Baiti IM, Cooper A, Lawlor ER, Kauer M, Ban J, Aryee DNT, Kovar H.
Intercohort gene expression co-analysis reveals chemokine receptors as prognostic indicators in Ewing’s sarcoma family tumors.
Clinical Cancer Research 16(14):3769-78 (2010)

Bachmaier R, Aryee DNT, Jug G, Kauer M, Kreppel M, Lee KA, Kovar H.
O-GlcNAcylation is involved in the transcriptional activity of EWS-FLI1 in Ewing's sarcoma.
Oncogene 28, 1280-1284 (2009).

Ban J, Bennani-Baiti I, Kauer M, Schaefer K-L, Poremba C, Jug G, Schwentner R, Smrzka O, Muehlbacher K, Aryee DNT, Kovar H.
EWS-FLI1 suppresses NOTCH-activated p53 in Ewing´s sarcoma.
Cancer Research 68(17), 7100-7109 (2008).

Aryee DNT, Kreppel M, Bachmaier R, Uren A, Muehlbacher K, Wagner S, Breiteneder H, Ban J, Toretsky JA, Kovar H.
Single-chain antibodies to the EWS NH2 terminus structurally discriminates between intact and chimeric EWS in Ewing’s sarcoma and interfere with the transcriptional activity of EWS in vivo.
Cancer Research 66(20), 9862-9869 (2006).

 

Grants

  1. Jubiläumsfonds der Österreichischen Nationalbank (ÖNB) Project # 14205. Therapeutic targeting of the tumor suppressor p53 in Ewing sarcoma family tumors. 3.1.2011 – 30.6.2012
  2. Jubiläumsfonds der Österreichischen Nationalbank (ÖNB) Project # 12675. Prognostic impact of hypoxia inducible factor HIF-1α and underlying biology in the Ewing sarcoma family of tumors. 1.2.2008 – 1.8.2009
  3. Jubiläumsfonds der Österreichischen Nationalbank (ÖNB) Project # 8404. Bispecific single-chain antibodies targeting EWS-FLI1 in Ewing sarcoma cells. 1.6.2000 – 1.6.2003