Immune cells out of control: how lethal hyperinflammation  emerges from a novel gene defect

Immune cells out of control: how lethal hyperinflammation emerges from a novel gene defect

(Vienna, 16.04.2021) Scientists at St. Anna Children’s Cancer Research Institute, together with their collaborators from Finland and Sweden, discover a novel subtype of a genetic disease: genetically determined deficiency of the protein RhoG abrogates the normal cytotoxic function of specific immune cells, causing hemophagocytic lymphohistiocytosis (HLH). These new findings may…